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Volume 117, Issue 5, Pages (November 1999)

PubblicatoDella Harrell Modificato 5 anni fa

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Presentazione sul tema: "Volume 117, Issue 5, Pages (November 1999)"— Transcript della presentazione:

1 Volume 117, Issue 5, Pages 1256-1257 (November 1999)
Relapsing ulcerative colitis after spinal cord stimulation: A case of intestinal neurogenic inflammation?  Giovanni Barbara, M.D., Roberto de Giorgio, M.D., Ph.D., Vincenzo Stanghellini, M.D., Paolo Gionchetti, M.D., Massimo Campieri, M.D., Roberto Corinaldesi, M.D.  Gastroenterology  Volume 117, Issue 5, Pages (November 1999) DOI: /S (99) Copyright © 1999 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Schematic representation of neurogenic inflammatory mechanisms. Antidromic stimulation of primary afferent nerves causes the release of substance P. The interaction of this neuropeptide with neurokinin-1 receptors (NK-1-R) localized on target cells evokes plasma extravasation and leukocyte adhesion and activation, leading to tissue inflammation. DRG, dorsal root ganglion. Gastroenterology  , DOI: ( /S (99) ) Copyright © 1999 American Gastroenterological Association Terms and Conditions

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