These diverse observations, taken together, embolden us to conclude that five distinct alterations suffice to transform normal human cells into tumor cells. Interestingly, only two or three of these changes seem to be required for rodent-cell transformation, explaining in retrospect the great difficulty experienced in early attempts to transform human cells. W.C: Hahn et al. New Engl J Med 347:1593-1603, 2002 Trasformazione in vitro di cellule umane
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