Incidence and Outcome of Invasive Fungal Diseases after Allogeneic Stem Cell Transplantation: A Prospective Study of the Gruppo Italiano Trapianto Midollo.

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Transcript della presentazione:

Incidence and Outcome of Invasive Fungal Diseases after Allogeneic Stem Cell Transplantation: A Prospective Study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) Corrado Girmenia, Anna Maria Raiola, Alfonso Piciocchi, Alessandra Algarotti, Marta Stanzani, Laura Cudillo, Clara Pecoraro, Stefano Guidi, Anna Paola Iori, Barbara Montante, Patrizia Chiusolo, Edoardo Lanino, Angelo Michele Carella, Elisa Zucchetti, Benedetto Bruno, Giuseppe Irrera, Francesca Patriarca, Donatella Baronciani, Maurizio Musso, Arcangelo Prete, Antonio Maria Risitano, Domenico Russo, Nicola Mordini, Domenico Pastore, Adriana Vacca, Francesco Onida, Sadia Falcioni, Giovanni Pisapia, Giuseppe Milone, Daniele Vallisa, Attilio Olivieri, Alessandro Bonini, Elio Castagnola, Simona Sica, Ignazio Majolino, Alberto Bosi, Alessandro Busca, William Arcese, Giuseppe Bandini, Andrea Bacigalupo, Alessandro Rambaldi, Anna Locasciulli Biology of Blood and Marrow Transplantation Volume 20, Issue 6, Pages 872-880 (June 2014) DOI: 10.1016/j.bbmt.2014.03.004 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence curve for IFDs among allo-HSCT recipients in the GITMO epidemiologic survey. Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Distribution of total allo-HSCTs performed and the number and rate of IFDs in the 30 transplantation centers. Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Timing of IFD. Early IFD refers to infection diagnosed on days 0-40 after allo-HSCT; late IFD, to infection diagnosed on days 41-100; and very late IFD, to infection diagnosed after day 100. Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Distribution of time to IFD stratified by type of GVHD. Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Cumulative incidence of IFD from GVHD onset by type of GVHD (A) and by type of donor (B). Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 6 Probability of 6-month survival after diagnosis of early PP-IFD, late PP-IFD, and very late PP-IFD. Biology of Blood and Marrow Transplantation 2014 20, 872-880DOI: (10.1016/j.bbmt.2014.03.004) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions