Volume 71, Issue 2, Pages (August 2019)

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Transcript della presentazione:

Volume 71, Issue 2, Pages 397-408 (August 2019) Update of the statements on biology and clinical impact of occult hepatitis B virus infection Giovanni Raimondo, Stephen Locarnini, Teresa Pollicino, Massimo Levrero, Fabien Zoulim, Anna S. Lok Jean-Pierre Allain, Thomas Berg, Antonio Bertoletti, Maurizia Rossana Brunetto, Raffaele Bruno, Ding-Shinn Chen, Nicola Coppola, Markus Cornberg, Antonio Craxì, Maura Dandri, Vito Di Marco, Carlo Ferrari, Giovanni Battista Gaeta, Dieter Glebe, Luca G. Guidotti, Anna Kramvis, Pietro Lampertico, Chengyao Li, Jake Liang, Alfredo Marzano, Thomas I. Michalak, Jean-Michel Pawlotsky, Daniele Prati, Massimo Puoti, Didier Samuel, Vincent Soriano, Giovanni Squadrito, Camille Sureau, Christian Trepo, Man-Fung Yuen Giovanni Raimondo, Stephen Locarnini, Teresa Pollicino, Massimo Levrero, Fabien Zoulim, Anna S. Lok Jean-Pierre Allain, Thomas Berg, Antonio Bertoletti, Maurizia Rossana Brunetto, Raffaele Bruno, Ding-Shinn Chen, Nicola Coppola, Markus Cornberg, Antonio Craxì, Maura Dandri, Vito Di Marco, Carlo Ferrari, Giovanni Battista Gaeta, Dieter Glebe, Luca G. Guidotti, Anna Kramvis, Pietro Lampertico, Chengyao Li, Jake Liang, Alfredo Marzano, Thomas I. Michalak, Jean-Michel Pawlotsky, Daniele Prati, Massimo Puoti, Didier Samuel, Vincent Soriano, Giovanni Squadrito, Camille Sureau, Christian Trepo, Man-Fung Yuen Journal of Hepatology Volume 71, Issue 2, Pages 397-408 (August 2019) DOI: 10.1016/j.jhep.2019.03.034 Copyright © 2019 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Schematic representation of HBV serum marker profile in naturally occurring OBI. AH, acute hepatitis; CH, chronic hepatitis; HBV, hepatitis B virus; OBI, occult HBV infection. Journal of Hepatology 2019 71, 397-408DOI: (10.1016/j.jhep.2019.03.034) Copyright © 2019 European Association for the Study of the Liver Terms and Conditions

Fig. 2 HBV genetic variants leading to the synthesis of HBsAg unrecognised by available assays or affecting its production/secretion. HBV, hepatitis B virus; HBsAg, HBV surface antigen. Journal of Hepatology 2019 71, 397-408DOI: (10.1016/j.jhep.2019.03.034) Copyright © 2019 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Schematic comparison of overt and occult HBV infection. Differences in amounts of total viral DNA, transcripts, proteins, formation and secretion of virions are exemplified. Diversity in packaging and transcriptional activities of HBV minichromosomes is also represented. Modified from Pollicino T. and Raimondo G., Journal of Hepatology 2015.131 cccDNA, covalently closed circular DNA; DC, dendritic cell; HATs, histone acetyltransferases; HDAC, histone deacetylase; HMT, histone methyltransferase; HBV, hepatitis B virus; HBsAg, HBV surface antigen; HSPG, heparan sulfate proteoglycan; NTCP, Na+-taurocholate cotransporting polypeptide; pgRNA, pregenomic RNA; rcDNA, relaxed circular DNA; SVPs, sub-viral particles; TF, transcription factor. Journal of Hepatology 2019 71, 397-408DOI: (10.1016/j.jhep.2019.03.034) Copyright © 2019 European Association for the Study of the Liver Terms and Conditions