Lucia Del Mastro Gruppo Italiano Mammella - GIM Napoli 10 marzo 2017

Presentazione sul tema: "Lucia Del Mastro Gruppo Italiano Mammella - GIM Napoli 10 marzo 2017"— Transcript della presentazione:

1 Lucia Del Mastro Gruppo Italiano Mammella - GIM Napoli 10 marzo 2017
Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2X2 factorial, randomised phase III study. Lucia Del Mastro Gruppo Italiano Mammella - GIM Napoli 10 marzo 2017 IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro

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3 W. Hryniuk

4 L. Norton

5 Istituto Nazionale per la Ricerca sul Cancro
IRCCS Azienda Ospedaliera Universitaria San Martino – IST Istituto Nazionale per la Ricerca sul Cancro M. Venturini P. Bruzzi

6 Dose-density Project Metastatic setting GM-CSF allows acceleration
of standard CEF (16 vs. 20 days) - GM-CSF allows intensification (1000/80/600) & acceleration of CEF Randomized trial of intensified accelerated CEF vs standard: no benefit Dose-dense was an other main research field at our institute both in metastatic and adjuvant setting

7 Dose-density Project Adjuvant setting
G-CSF allows acceleration of standard CEF (14 days) Dose-dense adjuvant chemotherapy in early breast cancer patients: results from a randomized trial HER2 expression and efficacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients Dose-dense was an other main research field at our institute both in metastatic and adjuvant setting

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10 Overall survival

11 GRUPPO ITALIANO MAMMELLA -GIM

12 CLINICAL TRIALS CARRIED OUT BY the Gruppo Italiano Mammella (GIM)
Type of study ACCRUAL TIME N° PATIENTS STATUS OF STUDY ENROLLEMENT GIM-1 Phase III Adjuvant CT, N- 25/11/ /06/2010 1636 COMPLETED GIM-2 Adjuvant CT, N+ 24/04/ /07/2006 2091 GIM-3 Adjuvant HT, postmenopausal 09/03/2007 – 31/07/2012 3707 GIM-4 01/08/ /05/2010 2056 GIM-5 Traslational , HT postmenopausal 12/08/2005 – 13/05/2008 488 GIM-6 Phase III, Fertility preservation 24/10/2003 – 01/02/2008 282 GIM-7 Targeted therapy metastatic disease 13/06/2008 – 21/12/2011 31 EARLY STOP GIM-8 Phase III, HT + targeted therapy metastatic disease 24/09/2008 30/04/2013 348 GIM-9 Phase II, neoadjuvant 09/12/2008 – 07/12/2010 47 GIM-10 Phase III, adjuvant, postmenopausal 12/11/ 2013 455 ONGOING

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14 a q3 EC-P arm b q3 FEC-P arm Therapy every 3 weeks Therapy every 3 weeks c d q2 EC-P arm q2 FEC-P arm Therapy every 2 weeks Therapy every 2 weeks 5-fluorouracil 600 mg/m2 i.v. Cyclophosphamide 600 mg/m2 i.v. Epirubicin 90mg/m2 i.v. Paclitaxel 175 mg/m2 i.v. over 3 hours

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21 ER+ ER-

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26 2016

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28 GIM (Gruppo Italiano per il trattamento del carcinoma della Mammella)
140 Italian Oncologic Centers GOIRC GOL GONO GOCSI GOV GISCAD