Volume 73, Issue 2, Pages (August 2016)

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Transcript della presentazione:

Volume 73, Issue 2, Pages 107-114 (August 2016) Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia Roberto Cangemi, Pasquale Pignatelli, Roberto Carnevale, Simona Bartimoccia, Cristina Nocella, Marco Falcone, Gloria Taliani, Francesco Violi Simona Battaglia, Giuliano Bertazzoni, Elisa Biliotti, Cinzia Myriam Calabrese, Marco Casciaro, Maurizio De Angelis, Paolo De Marzio, Rozenn Esvan, Lucia Fazi, Domenico Ferro, Lucia Fontanelli Sulekova, Cristiana Franchi, Laura Giordo, Stefania Grieco, Elisa Manzini, Sergio Morelli, Paolo Palange, Daniele Pastori, Marco Rivano Capparuccia, Giulio Francesco Romiti, Elisabetta Rossi, Eleonora Ruscio, Alessandro Russo, Maria Gabriella Scarpellini, Stefano Trapè, Filippo Toriello Roberto Cangemi, Pasquale Pignatelli, Roberto Carnevale, Simona Bartimoccia, Cristina Nocella, Marco Falcone, Gloria Taliani, Francesco Violi Simona Battaglia, Giuliano Bertazzoni, Elisa Biliotti, Cinzia Myriam Calabrese, Marco Casciaro, Maurizio De Angelis, Paolo De Marzio, Rozenn Esvan, Lucia Fazi, Domenico Ferro, Lucia Fontanelli Sulekova, Cristiana Franchi, Laura Giordo, Stefania Grieco, Elisa Manzini, Sergio Morelli, Paolo Palange, Daniele Pastori, Marco Rivano Capparuccia, Giulio Francesco Romiti, Elisabetta Rossi, Eleonora Ruscio, Alessandro Russo, Maria Gabriella Scarpellini, Stefano Trapè, Filippo Toriello Journal of Infection Volume 73, Issue 2, Pages 107-114 (August 2016) DOI: 10.1016/j.jinf.2016.05.013 Copyright © 2016 The British Infection Association Terms and Conditions

Figure 1 Linear regression analysis between baseline levels of sP-selectin, LPS (R = 0.554; p < 0.001) (panel A) and sNOX2-dp (R = 0.502; p < 0.001) (panel B); linear regression analysis between baseline levels of sNOX2-dp and LPS (R = 0.455; p < 0.001) (panel C). Journal of Infection 2016 73, 107-114DOI: (10.1016/j.jinf.2016.05.013) Copyright © 2016 The British Infection Association Terms and Conditions

Figure 2 Plasma sP-selectin (panel A), serum LPS (panel B), serum sNOX2-dp (panel C) and serum zonulin (panel D) levels at admission and discharge in CAP patients. **p < 0.001. Journal of Infection 2016 73, 107-114DOI: (10.1016/j.jinf.2016.05.013) Copyright © 2016 The British Infection Association Terms and Conditions

Figure 3 LPS and sP-selectin release: platelets were incubated with scalar concentrations of LPS (50–200 pg/ml) and stimulated with or without sub-threshold concentration (STC) of collagen (0.25 μg/ml) in presence or not of gp91ds-tat (a specific inhibitor of NOX2 activation, 50 μM) or control peptide (CP) (50 μM) (n = 5). *p < 0.05. Journal of Infection 2016 73, 107-114DOI: (10.1016/j.jinf.2016.05.013) Copyright © 2016 The British Infection Association Terms and Conditions