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Lanosterol Synthase Genetic Variants, Endogenous Ouabain, and Both Acute and Chronic Kidney Injury
Rossella Iatrino, Chiara Lanzani, Elena Bignami, Nunzia Casamassima, Lorena Citterio, Roberta Meroni, Laura Zagato, Alberto Zangrillo, Ottavio Alfieri, Simone Fontana, Lorenza Macrina, Simona Delli Carpini, Elisabetta Messaggio, Elena Brioni, Giacomo Dell’Antonio, Paolo Manunta, John M. Hamlyn, Marco Simonini American Journal of Kidney Diseases Volume 73, Issue 4, Pages (April 2019) DOI: /j.ajkd Copyright © 2018 The Authors Terms and Conditions
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Figure 1 Incidence of acute kidney injury (AKI) following cardiac surgery grouped according to lanosterol synthase (LSS) rs genotype. At any stage, the incidence of AKI increases with the number of LSS A alleles (χ2=13.68; P=0.001). Abbreviation: pts, patients. American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2018 The Authors Terms and Conditions
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Figure 2 Endogenous ouabain (EO) concentrations in human kidney samples grouped according to lanosterol synthase (LSS) rs genotype. The EO concentration in both cortex (red column) and medulla (blue column) is higher in tissues from patients with the LSS rs AA versus CC genotype. Data are expressed as nanogram of EO per gram of renal tissue (mean ± standard error of the mean). American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2018 The Authors Terms and Conditions
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Figure 3 Blood pressure (BP) during the follow-up period in the hypertensive cohort. No significant differences in systolic (SBP) and diastolic BP (DBP) values were found among the lanosterol synthase (LSS) genotype groups. The mean number of antihypertensive therapies used to maintain BP in the target range (<140/90mmHg) is reported. Data are expressed as mm Hg (mean values). American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2018 The Authors Terms and Conditions
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