Heart failure and anemia: Effects on prognostic variables

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Transcript della presentazione:

Heart failure and anemia: Effects on prognostic variables Gaia Cattadori, Piergiuseppe Agostoni, Ugo Corrà, Gianfranco Sinagra, Fabrizio Veglia, Elisabetta Salvioni, Alice Bonomi, Rocco La Gioia, Angela B. Scardovi, Alessandro Ferraironi, Michele Emdin, Marco Metra, Andrea Di Lenarda, Giuseppe Limongelli, Rosa Raimondo, Federica Re, Marco Guazzi, Romualdo Belardinelli, Gianfranco Parati, Sergio Caravita, Damiano Magrì, Carlo Lombardi, Maria Frigerio, Fabrizio Oliva, Davide Girola, Alessandro Mezzani, Stefania Farina, Massimo Mapelli, Domenico Scrutinio, Giuseppe Pacileo, Anna Apostolo, AnnaMaria Iorio, Stefania Paolillo, Pasquale Perrone Filardi, Paola Gargiulo, Maurizio Bussotti, Giovanni Marchese, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Pietro Palermo, Mauro Contini, Pantaleo Giannuzzi, Elisa Battaia, Mariantonietta Cicoira, Francesco Clemenza, Chiara Minà, Simone Binno, Claudio Passino, Massimo F. Piepoli European Journal of Internal Medicine Volume 37, Pages 56-63 (January 2017) DOI: 10.1016/j.ejim.2016.09.011 Copyright © 2016 European Federation of Internal Medicine. Terms and Conditions

Fig. 1 Hazard ratio according to Hemoglobin levels. Hazard Ratio of cardiovascular death+heart transplant for hemoglobin (Hb) (upper panel) and for patients grouped for high Hb, normal Hb, low Hb and very low Hb (lower panel). European Journal of Internal Medicine 2017 37, 56-63DOI: (10.1016/j.ejim.2016.09.011) Copyright © 2016 European Federation of Internal Medicine. Terms and Conditions

Fig. 2 Multivariable model for Hazard Ratio in the entire population. Hazard Ratio for association between peak oxygen consumption (VO2), ventilatory efficiency (VE/VCO2), Na+, left ventricle ejection fraction (LVEF), renal function (MDRD), Hb and cardiovascular death+heart transplant through study follow-up in the entire study population. Each variable is adjusted for the other variables of the model (VO2, VE/VCO2, Na+, LVEF, MDRD, Hb). European Journal of Internal Medicine 2017 37, 56-63DOI: (10.1016/j.ejim.2016.09.011) Copyright © 2016 European Federation of Internal Medicine. Terms and Conditions

Fig. 3 Population mortality according to Hemoglobin levels. Kaplan–Meier curves for cardiovascular death+heart transplant adjusted for age, gender adjusted for the proven confounders, i.e. peak VO2, VE/VCO2 slope, MDRD, LVEF and Na+ in the entire study population stratified according to Hb values: high Hb: >15g/dL (black line); normal Hb: 13–15g/dL for males and 12–15g/dL for females (green line); low Hb: 11–13g/dL for males and 11–12g/dL for females (red line); very low Hb: <11g/dL (blue line). The curves were arbitrarily ended at 10years. European Journal of Internal Medicine 2017 37, 56-63DOI: (10.1016/j.ejim.2016.09.011) Copyright © 2016 European Federation of Internal Medicine. Terms and Conditions

Fig. 4 Multivariable model for Hazard Ratio according to Hemoglobin group. Hazard Ratio for association between peak oxygen consumption (VO2), ventilatory efficiency (VE/VCO2), Na+, left ventricle ejection fraction (LVEF), renal function (MDRD), Hb and cardiovascular death+heart transplant through study follow-up in patients with normal Hb (left upper panel), high Hb (right upper panel), very low Hb (left lower panel) and low Hb (right lower panel). Each variable is adjusted for the other variables of the model (VO2, VE/VCO2, Na+, LVEF, MDRD). European Journal of Internal Medicine 2017 37, 56-63DOI: (10.1016/j.ejim.2016.09.011) Copyright © 2016 European Federation of Internal Medicine. Terms and Conditions