Figure 5-20a Molecular Biology of the Cell (© Garland Science 2008)

Presentazione sul tema: "Figure 5-20a Molecular Biology of the Cell (© Garland Science 2008)"— Transcript della presentazione:

1 Figure 5-20a Molecular Biology of the Cell (© Garland Science 2008)

2 DNA damages

3 Figure 5-45 Molecular Biology of the Cell (© Garland Science 2008)

4 Figure 5-47 Molecular Biology of the Cell (© Garland Science 2008)

5 Figure 5-48a Molecular Biology of the Cell (© Garland Science 2008)

6 Figure 5-46 Molecular Biology of the Cell (© Garland Science 2008)

7 Figure 5-48b Molecular Biology of the Cell (© Garland Science 2008)

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10 Xeroderma pigmentosum

11 Figure 5-51 Molecular Biology of the Cell (© Garland Science 2008)

12 Non- homologous end joining
Figure 5-52a Molecular Biology of the Cell (© Garland Science 2008)

13 Homologous recombination
Figure 5-59 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

14 Strand invasion RecA/RAD51
Figure Molecular Biology of the Cell (© Garland Science 2008)

15 Figure 5-59 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

16 HOLLIDAY Junctions Figure Molecular Biology of the Cell (© Garland Science 2008)

17 Branch migration

18 Branch resolution: Ruv C

19 Repair of replication fork breaks
Figure 5-53 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

20 Figure 5-53 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

21 Meiosis Rad51 Figure 5-64 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

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23 Figure 5-63 Molecular Biology of the Cell (© Garland Science 2008)

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26 Damage sensors Sensori diretti Sensori indiretti DNA glicosilasi
(Escissione di basi-BER) RPA-XPA-XPC (Global Genome Repair via Escissione di nucleotidi-NER) Sensori diretti Xeroderma pigmentosum (gr.A e gr.C) ATM-ATR-Ku70/80 Rotture a doppio filamento del DNA (Riparo per ricombinazione) Ataxia-telangectasia RNA polimerasi II/TFIIH (Transcription-Coupled Repair via Escissione di nucleotidi-NER) Sensori indiretti

27 Repair defects Escissione di nucleotidi-NER
XPB-XPD (subunità di TFIIH) XPF-XPG (nucleasi) XPE? Xeroderma pigmentosum (gr.B, D, F, G) Riparo per ricombinazione BRCA-2 Forme genetiche di cancro della mammella