Errori di Replicazione

Figure 5-20a Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-20b Molecular Biology of the Cell (© Garland Science 2008)

DNA damage depurinazione

Figure 5-45 Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-47 Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-48a Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-46 Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-48b Molecular Biology of the Cell (© Garland Science 2008)

NUCLEOTIDE EXCISION REPAIR (NER) IN EUKARYOTES

DNA repair defects and human diseases MALATTIA FENOTIPO Difetto Genetico e Meccanismo Cancro ereditario Carcinoma del colon (non poliposico) MSH2 Riparo di mismatch Xeroderma pigmentoso Cancro della pelle XP A-G Riparo per escissione Atassia teleangectasia Leucemie, linfomi ATM kinasi Riparo di dsb per Ricombinazione Cancro della mammella/ovaio BRCA-2 Riparo per ricombinazione Anemia di Fanconi Leucemie, anomalie congenite Riparo di legami crociati

Figure 5-51 Molecular Biology of the Cell (© Garland Science 2008)

NON-HOMOLOGOUS END JOINING (NHEJ) Figure 5-52a Molecular Biology of the Cell (© Garland Science 2008)

NON-HOMOLOGOUS END JOINING (NHEJ)

HOMOLOGOUS RECOMBINATION IN MEIOSIS Figure 5-64 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

HOMOLOGOUS RECOMBINATION IN MEIOSIS Figure 5-64 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

HOMOLOGOUS RECOMBINATION OF STALLED REPLICATION FORKS Figure 5-53 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-53 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

HOMOLOGOUS RECOMBINATION OF DOUBLE-STRAND BREAKS Figure 5-59 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-59 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)

Figure 5-54 Molecular Biology of the Cell (© Garland Science 2008)

Strand Invasion RecA/RAD51 Figure 5-56 Molecular Biology of the Cell (© Garland Science 2008)

HOLLIDAY JUNCTIONS Figure 5-61 Molecular Biology of the Cell (© Garland Science 2008)

JUNCTION MIGRATION: Ruv A/B PROTEINS

Sensori del Danno al DNA e Malattie Genetiche DNA glicosilasi (Escissione di basi-BER) RPA-XPA-XPC (Global Genome Repair via Escissione di nucleotidi-NER) Sensori diretti Xeroderma pigmentosum (gr.A e gr.C) ATM-ATR-Ku70/80 Rotture a doppio filamento del DNA (Riparo per ricombinazione) Ataxia-telangectasia RNA polimerasi II/TFIIH (Transcription-Coupled Repair via Escissione di nucleotidi-NER) Sensori indiretti

Effettori/Mediatori del Riparo e Malattie Genetiche Escissione di nucleotidi-NER XPB-XPD (subunità di TFIIH) XPF-XPG (nucleasi) XPE? Xeroderma pigmentosum (gr.B, D, F, G) Riparo per ricombinazione BRCA-2 Forme genetiche di cancro della mammella

MEIOSIS Figure 5-63 Molecular Biology of the Cell (© Garland Science 2008)

JUNCTION RESOLUTION: Ruv C