Presentazione sul tema: "BACKGROUND. Double-blinded, randomized, 6-days, crossover study Patients were admitted to the Department of Pediatric Federico II University, Naples."— Transcript della presentazione:
Double-blinded, randomized, 6-days, crossover study Patients were admitted to the Department of Pediatric Federico II University, Naples Italy Experimental preparation was given in the same amount of conventional starch according to patients diet Glucose, lactate, venous pH, serum insuline were measured before and after each meal 72h continuous glucose monitoring was performed The participants were asked to reproduce the everyday life as much as possible STUDY DESIGN
GSD1a G I 16 years I AM13 years C P 18 years R C 12 years A L 12,5 years S G 24 years GSD1b C M14 years M V 14 years M A25 years O N30 years PATIENTS 6 GSD1a 4 GSD1b
The experimental starch maintained blood glucose concentrations longer than did the traditional therapy in 2/3 GSD1a 1/2 GSD1b The daily amount of starch was reduced in 2/3 GSD1a, 1/2 GSD1b No significant effect was observed on insulin, lactic acid levels and venous pH No side effect was observed …not so tasty PRELIMINARY RESULTS
CONCLUSIONI AMIDO FISICAMENTE MODIFICATO VS AMIDO STANDARD Migliore controllo della glicemia Maggior riduzione dellacido lattico plasmatico Miglior assorbimento con minore fermentazione colica dellamido non digerito Nessuna differenza statisticamente significativa del profilo insulinico
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