Figure 5-20a Molecular Biology of the Cell (© Garland Science 2008)
DNA damages
Figure 5-45 Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-47 Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-48a Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-46 Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-48b Molecular Biology of the Cell (© Garland Science 2008)
Xeroderma pigmentosum
Figure 5-51 Molecular Biology of the Cell (© Garland Science 2008)
Non- homologous end joining Figure 5-52a Molecular Biology of the Cell (© Garland Science 2008)
Homologous recombination Figure 5-59 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)
Strand invasion RecA/RAD51 Figure 5-56 Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-59 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)
HOLLIDAY Junctions Figure 5-61 Molecular Biology of the Cell (© Garland Science 2008)
Branch migration
Branch resolution: Ruv C
Repair of replication fork breaks Figure 5-53 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-53 (part 2 of 2) Molecular Biology of the Cell (© Garland Science 2008)
Meiosis Rad51 Figure 5-64 (part 1 of 2) Molecular Biology of the Cell (© Garland Science 2008)
Figure 5-63 Molecular Biology of the Cell (© Garland Science 2008)
Damage sensors Sensori diretti Sensori indiretti DNA glicosilasi (Escissione di basi-BER) RPA-XPA-XPC (Global Genome Repair via Escissione di nucleotidi-NER) Sensori diretti Xeroderma pigmentosum (gr.A e gr.C) ATM-ATR-Ku70/80 Rotture a doppio filamento del DNA (Riparo per ricombinazione) Ataxia-telangectasia RNA polimerasi II/TFIIH (Transcription-Coupled Repair via Escissione di nucleotidi-NER) Sensori indiretti
Repair defects Escissione di nucleotidi-NER XPB-XPD (subunità di TFIIH) XPF-XPG (nucleasi) XPE? Xeroderma pigmentosum (gr.B, D, F, G) Riparo per ricombinazione BRCA-2 Forme genetiche di cancro della mammella