Mediterranean School of Oncology CINBO Consorzio Interuniversitario Nazionale pre la Bioncologia.

Presentazione sul tema: "Mediterranean School of Oncology CINBO Consorzio Interuniversitario Nazionale pre la Bioncologia."— Transcript della presentazione:

1 Mediterranean School of Oncology CINBO Consorzio Interuniversitario Nazionale pre la Bioncologia

2 Individuazione del bersaglio molecolare Gene profiling BINOMIO MOLECOLARE DIAGNOSTICO E TERAPEUTICO: STATO DELLARTE E PROSPETTIVE FUTURE Nuovi bersagli molecolari e loro applicazioni Bersagli molecolari selezionaticonsolidati e nuovi Bersagli molecolari selezionati: consolidati e nuovi Apoptosi, TRAIL Fattori di crescita e loro recettori Proteasoma Angiogenesi Regolazione trascrizionale ed epigenetica come bersaglio terapeutico Micro RNA: the New World Applicazioni nei tumori solidi e ematologici Mammella, Tratto GE, Polmone, Apparato Genitale Femminile, Mieloma, APL

3 Gene Profiling in the Prognostic Evaluation

4 Lung Breast Ovary

5 Receptor-type TK signalling Survival Growth Angiogenesis

6 Block of VEGF or EGFR in Cancer Treatment

7 Science Aug 2004 Science June 2004 Mutations of EGFR are pathogenetic and treatment sensitizing

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9 From Kaufmann & Vaux, Oncogene, 22: 7414, 2003 Alterations of apoptotic pathways in human cancer

10 NF-kB: a fundamental role in cancer pathogenesis, a target in cancer therapy Cytoplasmic nuclear transition A proteasome based regulation

11 Proteasome inhibitors: Velcade (bortezomib) The proteasome as a target of cancer therapy

12 Retinoic acid induces differentiation of APL blasts Expressing PML/RAR Expressing PML/RAR 10 -6 M (or RA 10 -9 M)

13 1983 Altered gene methylation in cancer 1989 Hypermethylation of a tumor suppressor gene in cancer Chromatin remodelling by deacetylation in human cancer 1998 Clinical trials with demethylating and deacetylase inhibiting agents 2003 Altered histone methylation in human cancer 2002 Landmarks in cancer epigenetics

14 Many HDAC Inhibitors are entering clinical trials

15 Chromatin remodelling in gene regulation

16 Micro-RNA: the future?