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Long α helix (α2) flanked on each side by a random coil loop (L1 or L2) and a short α helix (α1 or α3),

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Presentazione sul tema: "Long α helix (α2) flanked on each side by a random coil loop (L1 or L2) and a short α helix (α1 or α3),"— Transcript della presentazione:

1 long α helix (α2) flanked on each side by a random coil loop (L1 or L2) and a short α helix (α1 or α3),

2

3 HISTONE VARIANTS H2A.Z has apparently contradictory roles in gene activation and silencing; nucleosome turnover; DNA repair; heterochromatin heterochromatin

4 H2B NF-YB NC2 NC2 Pole4CHRAC14 H2A NF-YC CHRAC16 Pole3 TAF12 H3 H4 TAF6TAF9 Histone fold proteins TAF11TAF13 TAF6L TAF4 TAF4b TAF3 TAF10 YEATS2

5 TFIID

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7 NC2 NC2 NC2-TBP-TATA

8 Repression by NC2

9 TAF12 TAF6TAF9 TAF11TAF13 TAF4 TAF4b TAF3 TAF10 TFIID TAF1 Histone acetylation

10 TAF12 and TAF6 H2B-H4 interface

11 TAF11TAF13

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13 TAF12 TAF9 Histone acetylation TAF6L TAF4 TAF10 ? SAGA PCAF GCN5 Spt-Ada-Gcn5-acetyltransferase

14 NC2 NC2 Pole4CHRAC14 Histone acetylation YEATS2 ATAC Pole3 GCN5 ATAC2

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16 Nucleosome sliding hSNF2/ACF1 Pole4CHRAC14 CHRAC16 hCHRAC

17 DNA Pol DNA repair Pole4CHRAC14 Pole3

18 hSNF2H DPB1 DPB2 ACF/ CHRAC CHRAC16 CHRAC14 hACF1 DNA Pol DPB3 CHRAC14

19 NF-YBNF-YC NF-Y

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21 TAF10 TAF5 TAF11 TAF13 TAF7 TAF12 TAF1 TAF6 TAF9 NF-YB NF-YC TBP TAF3 TAF4 TAF2 NF-YA

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24 Cell.Cell Jan 17;152(1-2): doi: /j.cell Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination. Nardini MNardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R.Gnesutta NDonati GGatta RForni CFossati AVonrhein CMoras DRomier CBolognesi MMantovani R Source Dipartimento di BioScienze, Università degli Studi di Milano, Via Celoria 26, Milano, Italy Stem Cells.Stem Cells Nov;30(11): doi: /stem The short isoform of NF-YA belongs to the embryonic stem cell transcription factor circuitry. Dolfini DDolfini D, Minuzzo M, Pavesi G, Mantovani R.Minuzzo MPavesi GMantovani R Source Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milano, Italy.


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