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Hanahan & Weinberg: The hallmarks of cancer. Cell 100:57-70, 2000.

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TARGETED AGENTS IN ANTICANCER CHEMOTHERAPY.

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Presentazione sul tema: "Hanahan & Weinberg: The hallmarks of cancer. Cell 100:57-70, 2000."— Transcript della presentazione:

1 Hanahan & Weinberg: The hallmarks of cancer. Cell 100:57-70, 2000

2 ONCOGENE ACTIVATION

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4 TUMOR SUPPRESSOR INACTIVATION p53

5 TUMOR SUPPRESSOR INACTIVATION

6 Locus 9p21

7 TUMOR SUPPRESSOR INACTIVATION

8 Protein-protein interactions TUMOR SUPPRESSOR INACTIVATION

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12 Cellula normale Cellula tumorale PTEN INIBITORI DI mTOR effetti lievi attività PI3K/Akt/mTOR attività PI3K/Akt/mTOR PTEN

13 Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addictiona rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448– /ncponc0558 Table 1 Examples of oncogene addiction: studies in mice

14 Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addictiona rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448– /ncponc0558 Table 2 Examples of oncogene addiction: studies in human cancer cell lines

15 Weinstein IB and Joe AK (2006) Mechanisms of Disease: oncogene addictiona rationale for molecular targeting in cancer therapy Nat Clin Pract Oncol 3: 448– /ncponc0558 Table 3 Clinical evidence of oncogene addiction

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20 Cellula normale Cellula tumorale Rb attività E2F espressione gene A espressione gene B espressione gene topoisomerasi II espressione gene C VELENI DELLA TOPO II SOPRAVVIVENZA blocco attività E2F

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22 % B inhibition

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25 INIBIT GENE EXPRESSION INIBIT PROTEIN FUNCTION AS-ODN siRNA mAbs Small molecule inhibitors


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